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Correction

Virulence Factors of Pasteurellaceae, Formidable Animal Pathogens

In the April 2002 issue of ASM News, p. 176, it is stated that the LPS and CPS mutants generated by Jacques et al. are the first and to date only set of isogenic mutants of A. pleuropneumoniae surface polysaccharides. However, in the July 1998 issue of Infection and Immunity, Christine Ward et al. described an isogenic, knockout mutation in the capsular polysaccharide DNA biosynthesis region of A. pleuropneumoniae serotype 5, generated by allelic exchange mutagenesis (Infect. Immun. 66:3326-3336). This work was first published and presented at the HAP conference in Mexico in 1996 (C. K. Ward and T. J. Inzana, Mutations in capsular polysaccharide biosynthesis render Actinobacillus pleuropneumoniae avirulent. Abstract 25, Haemophilus, Actinobacillus, Pasteurella 96 International Conference, Acapulco, Mexico, 1996). This mutant was avirulent in swine and has a specific deletion in the biosynthesis region and therefore cannot make CPS, unlike the Tn mutant described in the ASM News article, which cannot export the polysaccharide. This report of the allelic exchange mutant was the first description of an isogenic mutant of an A. pleuropneumoniae polysaccharide.