November, 2002
Table of Contents

Reflections on Cellulolysis
p.532
Bernard Dixon

RNA Interference Technique Blocks HIV among Potential Targets
p.534
West Nile Virus Epidemic Expands, Even by Transplant Organs, Blood
p.535
U.S., Canadians, Europeans Endorse Restricted Animal Antimicrobial Uses
p.536
Water Safety from Micro
p.537
. . . to Global p.538
NIH, WHO, and World Bank Launch Disease Control Priorities Project
p.538
Raccoons, Parasites Have Bioterrorism Potential
p.530
New Drug for Treating Hepatitis B, but Problems with Hepatitis A Vaccines
p.540

Human BPI: One Protein's Journey from
Laboratory into Clinical Trials p.543 [PDF]
Lesa Beamer
Challenges and frustrations attend efforts to bring
this and other proteins with promising activity into clinical use as
therapeutics
Hypermutation and Bacterial Adaptation
p.549 [PDF]
Christopher D. Bayliss and E. Richard Moxon
High rates of localized or generalized mutation help
some pathogens adapt to host environments and may enhance virulence
Directed Evolution To Produce
Enantioselective Biocatalysts p.556 [PDF]
Karl-Erich Jaeger, Manfred T. Reetz, and Bauke W. Dijkstra
Although protocols for improving enzyme enantioselectivity are not
standardized, changes to increase flexibility work on a bacterial lipase

Plant-Associated Microbe Genome
Initiative p.529
Restricted Use of Antibiotics in
Agriculture p.529
Proper Credit Is Due p.529
A More Palatable H. pylori:
Iterative Model-Building through the Peer-Review Process p.529